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Ken Pugh
Ken Pugh
Haskins Laboratories
300 George Street
New Haven, CT 06511

Haskins Phone: (203) 865-6163, x224
Yale Phone: (203) 764-9353
Haskins Fax: (203) 865-8963

Regular Days at Haskins: Monday - Friday

Education

Ph.D. (Experimental Psychology), The Ohio State University , 1990
M.A. (Experimental Psychology), The Ohio State University , 1987
B.S. (Psychology), Summa Cum Laude, New York Institute of Technology, 1982

 

Representative Publications and Presentations

Pugh, K., Rexer, K., Peter, M., & Katz, L. (1994). Neighborhood effects in visual word recognition:  Effects of letter delay and nonword context difficulty. Journal of Experimental Psychology: Learning, Memory, and Cognition, 20, 639-648.

Shaywitz, B., Shaywitz, S., Pugh, K., Constable, T., Skudlarski, P., Fulbright, R., Bronen, R., Fletcher, J., Shankweiler, D., Katz, L., & Gore, J. (1995). Sex differences in the functional organization of the brain for language. Nature, 373, 607-609.

Pugh, K., Shaywitz, B., Constable, T., Shaywitz, S., Skudlarski, P., Fulbright, R., Bronen, R., Shankweiler, D., Katz, L., Fletcher, J., & Gore, J. (1996). Cerebral organization of component processes in reading.  Brain, ,119, 1221-1238.

Pugh, K., Shaywitz, B. A., Shaywitz, S. E., Fulbright, R. K., Byrd, D., Skudlarski, P., Shankweiler, D. P., Katz, L., Constable, R. T., Fletcher, J., Lacadie, C., Marchione, K., & Gore, J. C.. (1996). Auditory selective attention:  An fMRI investigation. NeuroImage, 4, 159-173.

Pugh, K., Shaywitz, B., Shaywitz, S., R., Shankweiler, D., Katz, L., Fletcher, J., Constable, R. T., Skudlarski, P., Fulbright, R., Bronen, R. & Gore, J. (1997). Predicting reading performance from neuroimaging profiles: The cerebral basis of phonological effects in printed word identification. Journal of Experimental Psychology: Human Perception and Performance, 23, 299-318.

Shaywitz, B., Shaywitz, S., Pugh, K., R., Fulbright, Constable, T., Mencl, E., Skudlarski, Liberman, A. R., Shankweiler, D., Katz, L., Fletcher, J., Lacadie, C., Marchione, K., Gatenby, C., & Gore, J. (1998). Functional disruption in the organization of the brain for reading in dyslexia.  Proceedings of the National Academy of Sciences, 95, 2636-2641.

Shaywitz, S., Shaywitz, B., Pugh, K., Fulbright, R., Constable, R. T., Mencl, W.E., Naftolin, F., Skudlarski, P., Fletcher, J., Marchione, K., Lacadie, C., Gatenby, C., Klorman, R., & Gore, J. (1999). Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks. Journal of the American Medical Association, 281, 1197-1202.

Pugh, K., Mencl, E.W., Shaywitz, B. A., Shaywitz, S. E., Fulbright, R. K., Skudlarski, P., Constable, R. T.,  Marchione, K., Jenner A.R.,  Shankweiler, D. P., Katz, L., Fletcher, J., Lacadie, C., & Gore, J. C.. (2000). The angular gyrus in developmental dyslexia: Task-specific differences in functional connectivity in posterior cortex,  Psychological Science, 11, 51-56.

Pugh, K.R., Mencl, W.E., Jenner, A.J., Katz, L., Frost, S.J., Lee, J.R., Shaywitz, S.E., & Shaywitz, B.A. (2000). Functional neuroimaging studies of reading and reading disability (developmental dyslexia). Mental Retardation and Developmental Disabilites Review, 6(3), 207-213.

Shaywitz, B.A., Shaywitz, S.E., Pugh, K., R., Mencl, W.E., Fulbright, R.K.,  Skudlarski, P. Constable, R.T.,  Marchione, K.E., Fletcher, J.M.,   Lyon, G.R., & Gore, J.C. (2002). Disruption of posterior brain systems for reading in children with developmental dyslexia. Biological Psychiatry, 52, 101-110.

Shaywitz, B.A, Shaywitz, S.E, Blachman, B,. Pugh, K.R., Fulbright, R, Skudlarski, P, Mencl, E.M. Constable, R.T., Holahan, J., Marchione, K.E.,. Fletcher, J., Lyon, G.R. & Gore, J. (2004). Development of Left Occipito-Termporal Systems for Skilled Reading Following a Phonologically-Based Intervention in Children.. Biological Psychiatry. 55, 926-933.

Jacobsen LK, D’Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH (2004). Nicotine effects on brain function and functional connectivity in schizophrenia, Biological Psychiatry, 55, 850-858.

Sandak, R., Mencl, W. E., Frost, S. J., Rueckl, J. G., Katz, L., Moore, D., Mason, S. M., Fulbright, R. K., Constable, R. T., Pugh, K. R. (2004). The neurobiology of adaptive learning in reading: A contrast of different training conditions. Cognitive, Affective, & Behavioral Neuroscience, 4, 67-88.

Katz, L., Lee, C. H., Tabor, W., Frost, S. J., Mencl, W. E., Sandak, R., Rueckl, J. G., Pugh, K. R. (2005). Effects of printed word repetition in lexical decision and naming on behavior and brain activation, Neuropsychologia, 43, 2068-2083.

Frost, S. J., Mencl, W. E., Sandak, R., Moore, D. L., Rueckl, J., Katz, L., Fulbright, R. K., & Pugh, K. R. (2005). An fMRI study of the trade-off between semantics and phonology in reading aloud. Neuroreport, 16, 621-624.

Pugh, K. R., Sandak, R., Frost, S. J., Moore, D., & Mencl, W. E. (2005). Examining reading development and reading disability in English language learners: Potential contributions from functional neuroimaging. Learning Disabilities Research & Practice, 20 (1), 24-30.

Pugh, K. R., Sandak, R., Frost, S. J., Moore, D., & Mencl, W. E. (2006). Examining Reading Development and Reading Disability in Diverse Languages and Cultures: Potential Contributions from Functional Neuroimaging. Journal of American Indian Education, 45(3), 60-76.

Jacobsen, L.K., Pugh, K.R., Mencl, W.E., & Gelernter, J. (2006). C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency. Psychopharmacology, 188, 530-540.

Jacobsen, L.K., Slotkin, T.A., Westerveld, M., Mencl, W.E., & Pugh, K.R. (2006). Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smoking. Neuropsychopharmacology, 31, 1550-1561.

Cutting, L.E., Clements, A.M., Courtney, S., Rimrodt, S., Schafer, J., Bisesi, J., & Pekar, J.J., Pugh, K.R. (2006). Differential components of sentence comprehension: Beyond single word reading and memory. Neuroimage, 15:29, 429-438.

Ment, L.R., Peterson, B.S., Vohr, B., Allan, W., Schneider, K.C., Lacadie, C., Katz, K.H., Maller-Kesselman, J., Pugh, K.R., Duncan, C.C., Makuch, R.W., &Constable, R.T. (2006). Cortical recruitment patterns in prematurely-born children compared to controls during a passive listening fMRI task. Journal of Pediatrics, 149(4), 490-498.

Pugh, K.R. (2006). A neurocognitive overview of reading acquisition and dyslexia across languages. Developmental Science, 448-450.

Pugh, K. R., Sandak, R., Frost, S. J., Moore, D., & Mencl, W. E., (2006). Neurobiological investigations of skilled and impaired reading. In D. K. Dickinson & S. B. Neuman (Eds.), Handbook of Early Literacy Research, Vol. II. New York: Guilford Publications.

Pugh, K. R., Frost, S. J., Sandak, R., Gillis, M., Moore, D., Jenner, A. R., & Mencl, W. E. (2006). What does reading have to tell us about writing: Preliminary questions and methodological challenges in examining the neurobiological foundations of writing and writing disabilities. In C. MacArthur, S. Graham, & J. Fitzgerald (Eds.). Handbook of Writing Research. New York: Guilford.

Pugh, K. R., Sandak, R., Frost, S. J., Moore, D., Rueckl, J. G., & Mencl, W. E. (2006). Neurobiological studies of skilled and impaired reading: A work in progress. In G. D. Rosen (Ed.), The Dyslexic Brain: New Pathways in Neuroscience Discovery. Baltimore: York Press.

Jacobsen, L.K., Pugh, K.R., Constable, R.T., Westerveld, M., & Mencl, W.E. (2007). Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis users. Biological Psychiatry, 61, 31-40.

Jacobsen LK, Slotkin TA, Mencl WE, Frost SJ, Pugh KR (2007): Gender specific
effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attention, Neuropsychopharmacology, 32: 2453-2464.

Jacobsen LK, Mencl WE, Constable RT, Westerveld M, Pugh KR (2007): Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers, Psychopharmacology, 193: 557-566.

Pugh, K. R., Frost, S. J., Sandak, R., ., Landi, N., Rueckl, J. G., Constable, R.T, Fulbright, R., Katz, L., & Mencl, W. E (2008). Effects of stimulus difficulty and repetition on printed word identification: An fMRI comparison of Non-Impaired and Reading Disabled Adolescent cohorts. Journal of Cognitive Neuroscience. 20 7,1146-1160.

Frost, S. J., Sandak, R., Mencl, W. E., Landi, N., Moore, D., Della Porta, G., Rueckl, J. G., Katz, L., & Pugh, K. R. (2008). Neurobiological and behavioral studies of skilled and impaired word reading. In In E. Grigorenko & A. Naples (Eds.). Single-Word Reading: Biological and Behavioral Perspectives. Mahwah: Erlbaum.

Shankweiler, D. P., Mencl, W. E., Braze, D., Tabor, W., Pugh, K. R., & Fulbright, R. K. (2008). Reading Differences and Brain: Cortical Integration of Speech and Print in Sentence Processing Varies with Reader Skill. Developmental Neuropsychology, 33(6), 745-776.

Frost, S.J., Landi, N., Mencl, W.E., Sandak., R., Fulbright, R.K., Tejada, E., Jacobsen, L., Grigorenko, E.L., Constable, R.T., & Pugh, K.R. (2009). Phonological awareness predicts activation patterns for print and speech. Annals of Dyslexia, 58, 78-97.

Frost, S.J., Sandak, R., Mencl, W.E., Landi, N., Rueckl, J.G., Katz, L., and Pugh, K.R. (2009).  Mapping the Word Reading Circuitry in Skilled and Disabled Readers.  In P. McCardle & K. Pugh, (Eds.). Helping Children Learn To Read: Current Issues and New Directions in the Integration of Cognition, Neurobiology and Genetics of Reading and Dyslexia Research and Practice, Psychology Press, 3-19. 

Mencl, W.E., Frost, S.J. and Pugh, K.R. (2009). Tools for multimodal imaging. In P. McCardle & K. Pugh, (Eds.). Helping Children Learn To Read: Current Issues and New Directions in the Integration of Cognition, Neurobiology and Genetics of Reading and Dyslexia Research and Practice.

Pugh, K.R. and McCardle, P. (2009).  Conclusion:  Integration of Methodologies in Cognitive Neuroscience-Research, Planning and Policy.  In P. McCardle & K. Pugh, (Eds.), How Children Learn To Read:  Current Issues and New Directions In The Integration of Cognition, Neurobilogy and Genetics of Reading and Dyslexia Research and Practice, Psychology Press, 301-311.

Rimrodt S.L., Clements-Stephens A.M., Pugh K.R., Courtney S.M, Gaur P, Pekar J.J., Cutting L.E. (2009). Functional MRI of Sentence Comprehension in Children with Dyslexia: Beyond Word Recognition. Cerebral Cortex, Feb;19(2):402-13.

Schafer, R.J., Lacadie, C., Vohr, B., Kesler, S.R., Katz, K.H., Schneider, K.C., Pugh, K.R., Makuch, R.W., Reiss, A.L., Constable, R.T., and Ment, L.R. (2009).  Alterations in functional connectivity for language in prematurely born adolescents.  Brain, v. 132, pp. 661-670.

Landi, N., Mencl, W.E., Frost, S.J., Sandak, R., Pugh, K.R. (2010).  An fMRI study of multimodal semantic and phonological processing in reading disabled adolescents.  Annals of Dyslexia, v. 60, 102-121.

Myers, E.H., Hampson, M., Vohr, B., Lacadie, C., Frost, S.J., Pugh, K.R., Katz, K.H., Schneider, K.C., Makuch, R.W., Constable, R.T., Ment, L.R. (2010).  Functional connectivity to a right hemisphere language center in prematurely born adolescents.  NeuroImage, v.51, pp. 1445-1452.

Preston, J.L., Frost, S.J., Mencl, W.E., Fulbright, R.K., Landi, N., Grigorenko, E., Jacobsen, L., and Pugh, K.R. (2010).  Early and late talkers:  school-age language, literacy and neurolinguistic differences.  Brain, v. 133, 2185-2195.

Pugh, K.R., Frost, S.J., Sandak, R.,Landi, N., Moore, D., Della Porta, G., Rueckl, J.G., and W. Einar Mencl. (2010).  Mapping the Word Reading Circuitry in Skilled and Disabled Readers.  In P. L. Cornelissen, P. C. Hansen, M. L. Kringelbach and K. Pugh, (Eds.), The Neural Basis of Reading, Oxford Press, 281-305.

Braze, D., Mencl, W.E., Tabor, W., Pugh, K.R., Constable, R.T., Fulbright, R.K., Magnuson, J.S., Van Dyke, J.A. & Shankweiler, D.P. (2011).  Unification of Sentence processing via ear and eye:  An fMRI study.  Cortex, v. 47, pp. 416-431.

Das, T., Padakannaya, P., Pugh, K.R., Singh, N.C. (2011).  Neuroimaging reveals dual routes to reading in simultaneous proficient readers of two orthographies.  NeuroImage, v. 54, pp. 1476-1487.

Diehl, J.J., Frost, S.J., Mencl, W.E., Pugh, K.R. (2011).  Neuroimaging and the Phonological Deficit Hypothesis.In Explaining Individual Differences in Reading, Theory and Evidence, (Ed.) Brady, S.A., Braze, D., Fowler, C.A., Psychology Press, 2011, pp. 217-237.

Magnuson, J.S., Kukona, A., Braze, D., Johns, C.L., Van Dyke, J.A., Tabor, W., Mencl, W.E., Pugh, K.R., and Shankweiler, D.P. (2011). Phonological Instability in Young Adult Poor Readers. In Dyslexia Across Languages, Orthography and the Brain-Gene-Behavior Link, (Ed.) McCardle, P., Miller, B., Lee, J.R., Tzeng, O.J.L., Paul H. Brookes Publishing Co, 2011, pp. 184-201.

Pugh, K.R., Landi, N. Preston, J.L. ,Mencl, E.W.,Austin, A.C., Sibley, D., Fulbright, R.K., Seidenberg, M.S., Grigorenko, E.L., Constable, R.T., Molfese, P., Frost, S.J. (2013). The relationship between phonological and auditory processing and brain organization in beginning readers. Brain and Language, Volume 125, Issue 2, May 2013, Pp 173-183.

Pugh, K.R., Frost, S.J., Rothman, D.L., Hoeft, F. Del Tufo, S.N., Mason, G.F., Molfese, P.J., Mencl, W.E., Grigorenko, E.L., Landi, N., Preston, J.L., Jacobsen, L., Seidenberg, M.S., Fulbright, R.K. (2014). Glutamate and Choline levels predict individual differences in reading ability in emergent readers. Journal of Neuroscience, 34(11), p.4082-4089.